Investigation of [¹¹C]carfentanil for mu opioid receptor quantification in the rat brain.

ABSTRACT: [¹¹C]Carfentanil ([¹¹C]CFN) is the only selective carbon-11 labeled radiotracer currently available for positron emission tomography (PET) imaging of mu opioid receptors (MORs). Though used extensively in clinical research, [¹¹C]CFN has not been thoroughly characterized as a tool for preclinical PET imaging. As we were occasionally observing severe vital sign instability in rat [¹¹C]CFN studies, we set out to investigate physiological effects of CFN mass and to explore its influence on MOR quantification. In anesthetized rats (n = 15), significant dose-dependent PCO₂ increases and heart rate decreases were observed at a conventional tracer dose range (IV, > 100 ng/kg). Next, we conducted baseline and retest [¹¹C]CFN PET scan

SUBMITTER: Kelleher AC 

PROVIDER: S-EPMC11250808 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature