Prescription Trends of Thiazide Diuretics in a Canadian Primary Care Population From 2015 to 2021.

ABSTRACT:

Background

Hypertension Canada 2017 guidelines favoured the use of thiazide (TZ)-like diuretics, such as CLTD (chlorthalidone) and indapamide (IND) over hydrochlorothiazide (HCTZ). Health Canada warned in 2019 that HCTZ may be associated with increased risk of skin cancer. Our study looked at the changes in TZ prescriptions from 2015 to 2021 in Ontario, Canada.

Methods

A retrospective cohort study was conducted of adults with hypertension, using electronic medical record data from the University of Toronto Practice-Based Research Network database covering mostly the Greater Toronto area. Outcomes included the proportion of patients who received a prescription of HCTZ, CLTD, or IND each month. Interrupted time-series analysis was used to evaluate the change in outcomes after

SUBMITTER: Ji C 

PROVIDER: S-EPMC11250860 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature