New Opportunities and Old Challenges in the Clinical translation of Nanotheranostics.

ABSTRACT: Nanoparticle-based systems imbued with both diagnostic and therapeutic functions, known as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing active responses to endogenous and exogenous biophysical stimuli, and stratifying patients for optimal treatment. However, although in recent years more nanotechnological platforms and techniques have been implemented in the clinic, several important challenges remain that are specific to nanotheranostics. In this Review, we first discuss some of the many ways of 'constructing' nanotheranostics, focusing on the different imaging modalities and therapeutic strategies. We then outline nanotheranostics that are currently used in humans at different stages of clinical development, identifying specific advantages and opp

SUBMITTER: Gawne PJ 

PROVIDER: S-EPMC11251001 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature