Lymphopenia in the Adult Population With Fontan Physiology: A Potential New Marker for Disease Assessment.

ABSTRACT:

Background

Patients with complex congenital heart disease and Fontan palliation frequently develop extracardiac disease, including hematologic abnormalities, such as lymphopenia. However, the clinical implications of this finding are poorly understood and are therefore the topic of this investigation.

Methods

Patients with Fontan physiology in our centre (1999-2018) were evaluated for the presence and impact of lymphopenia. The cohort was divided into a group with lymphopenia (L) (2 consecutive absolute lymphocyte counts ≤ 1∗10³ K/ μL) and a group who had never had lymphopenia (NL). Clinical characteristics and hospital admissions (762 patient-years) were evaluated.

Results

In 62 adult patients with Fontan physiology (aged 34 ± 9 years; 32 women [52%]), the

SUBMITTER: Scandinaro AL 

PROVIDER: S-EPMC11251074 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature