Hypercapnia and lung function parameters in chronic obstructive pulmonary disease.

ABSTRACT:

Background

In advanced chronic obstructive pulmonary disease (COPD), hypercapnia may occur due to severe bronchial obstruction with lung hyperinflation. Non-invasive ventilation (NIV) provides the standard of care intended to achieve physiological PCO₂ levels, thereby reducing overall mortality. The present study aimed to evaluate pulmonary function parameters derived from spirometry (forced vital capacity [FVC], forced expiratory volume in 1 s [FEV1]), body plethysmography (residual volume [RV], total lung capacity [TLC]), and lung diffusion capacity for carbon monoxide (single-breath method [DCO-SB], alveolar-volume corrected values [DCO-VA]) as predictors of chronic hypercapnia in patients with advanced COPD.

Methods

This monocentric, retrospective observationa

SUBMITTER: Gernhold L 

PROVIDER: S-EPMC11251095 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature