Intratumoral microbiome of adenoid cystic carcinomas and comparison with other head and neck cancers.

ABSTRACT: Adenoid cystic carcinoma (ACC) is a rare, usually slow-growing yet aggressive head and neck malignancy. Despite its clinical significance, our understanding of the cellular evolution and microenvironment in ACC remains limited. We investigated the intratumoral microbiomes of 50 ACC tumor tissues and 33 adjacent normal tissues using 16S rRNA gene sequencing. This allowed us to characterize the bacterial communities within the ACC and explore potential associations between the bacterial community structure, patient clinical characteristics, and tumor molecular features obtained through RNA sequencing. The bacterial composition in the ACC was significantly different from that in adjacent normal salivary tissue, and the ACC exhibited diverse levels of species richness. We identified two main m

SUBMITTER: Karpinets TV 

PROVIDER: S-EPMC11251153 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature