Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity.

ABSTRACT: Neural states of impairment from intoxicating substances, including cannabis, are poorly understood. Cannabinoid 1 receptors, the main target of Δ9-tetrahydrocannabinol (THC), the primary intoxicating cannabinoid in cannabis, are densely localized within prefrontal cortex; therefore, prefrontal brain regions are key locations to examine brain changes that characterize acute intoxication. We conducted a double-blind, randomized, cross-over study in adults, aged 18-55 years, who use cannabis regularly, to determine the effects of acute intoxication on prefrontal cortex resting-state measures, assessed with portable functional near-infrared spectroscopy. Participants received oral THC (10-80 mg, individually dosed to overcome tolerance and achieve acute intoxication) and identical placebo, ra

SUBMITTER: Karunakaran KD 

PROVIDER: S-EPMC11251178 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature