Stochastic journeys of cell progenies through compartments and the role of self-renewal, symmetric and asymmetric division.

ABSTRACT: Division and differentiation events by which cell populations with specific functions are generated often take place as part of a developmental programme, which can be represented by a sequence of compartments. A compartment is the set of cells with common characteristics; sharing, for instance, a spatial location or a phenotype. Differentiation events are transitions from one compartment to the next. Cells may also die or divide. We consider three different types of division events: (i) where both daughter cells inherit the mother's phenotype (self-renewal), (ii) where only one of the daughters changes phenotype (asymmetric division), and (iii) where both daughters change phenotype (symmetric division). The self-renewal probability in each compartment determines whether the progeny of a s

SUBMITTER: Dreiwi H 

PROVIDER: S-EPMC11251179 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature