Reduced plasma glycine concentration in healthy and chronically diseased older adults: a marker of visceral adiposity?

ABSTRACT:

Background

Previous studies have shown that a reduced plasma concentration of the amino acid glycine (Gly) is associated with intra-abdominal obesity, but the mechanism remains unclear.

Objectives

This study aimed to investigate whether lower plasma Gly concentrations in older adults are independently associated with (visceral) adiposity, age, sex, presence of chronic disease, and glucose intolerance, and whether they are caused by a reduced Gly whole-body production (WBP) and/or increased Gly disposal capacity.

Methods

We studied 102 older adults (47 males/55 females, 68.5 ± standard deviation 6.4 y) without comorbidities and 125 older adults with chronic obstructive pulmonary disease (COPD) (58 males/67 females, 69.7 ± 8.6 y). We assessed body composition and viscer

SUBMITTER: Deutz LN 

PROVIDER: S-EPMC11251212 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature