Imbalanced temporal states of cortical blood-oxygen-level-dependent signal variability during rest in episodic migraine.

ABSTRACT:

Background

Migraine has been associated with functional brain changes including altered connectivity and activity both during and between headache attacks. Recent studies established that the variability of the blood-oxygen-level-dependent (BOLD) signal is an important attribute of brain activity, which has so far been understudied in migraine. In this study, we investigate how time-varying measures of BOLD variability change interictally in episodic migraine patients.

Methods

Two independent resting state functional MRI datasets acquired on 3T (discovery cohort) and 1.5T MRI scanners (replication cohort) including 99 episodic migraine patients (n_3T = 42, n_1.5T=57) and 78 healthy controls (n_3T = 46, n_1.5T=32) were analyzed in this

SUBMITTER: Vereb D 

PROVIDER: S-EPMC11251240 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature