Abnormal intrinsic functional hubs and connectivity in patients with post-stroke depression.

ABSTRACT:

Objective

The present study aimed to investigate the specific alterations of brain networks in patients with post-stroke depression (PSD), and further assist in elucidating the brain mechanisms underlying the PSD which would provide supporting evidence for early diagnosis and interventions for the disease.

Methods

Resting-state functional magnetic resonace imaging data were acquired from 82 nondepressed stroke patients (Stroke), 39 PSD patients, and 74 healthy controls (HC). Voxel-wise degree centrality (DC) conjoined with seed-based functional connectivity (FC) analyses were performed to investigate the PSD-related connectivity alterations. The relationship between these alterations and depression severity was further examined in PSD patients.

Results

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SUBMITTER: Wu X 

PROVIDER: S-EPMC11251479 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature