Modifiable factors associated with Huntington's disease progression in presymptomatic participants.

ABSTRACT:

Objective

Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms. Our aim here was to identify factors that can be modified to slow disease progression even before the first symptoms appear.

Methods

We included 2636 presymptomatic individuals (comparison with family controls) drawn from the prospective observational cohort Enroll-HD, with more than 35 CAG repeats and at least two assessments of disease progression measured with the composite Huntington's disease rating Scale (cUHDRS). The association between sociodemographic factors, health behaviors, health history, and cUHDRS trajectory was assessed with a mixed-effects random forest using partial dependence plots and Shapley additive explanation me

SUBMITTER: Gil-Salcedo A 

PROVIDER: S-EPMC11251488 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature