Comparing Phylogeographies to Reveal Incompatible Geographical Histories within Genomes.

ABSTRACT: Modern phylogeography aims at reconstructing the geographic movement of organisms based on their genomic sequences and spatial information. Phylogeographic approaches are often applied to pathogen sequences and therefore tend to neglect the possibility of recombination, which decouples the evolutionary and geographic histories of different parts of the genome. Genomic regions of recombining or reassorting pathogens often originate and evolve at different times and locations, which characterize their unique spatial histories. Measuring the extent of these differences requires new methods to compare geographic information on phylogenetic trees reconstructed from different parts of the genome. Here we develop for the first time a set of measures of phylogeographic incompatibility, aimed at de

SUBMITTER: Singer B 

PROVIDER: S-EPMC11251493 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature