Evaluation of an automated platelet aggregation method for detection of congenital or acquired platelet function defects.

ABSTRACT:

Background

Light transmission aggregometry (LTA) is the most widely used laboratory method for an initial screening of patients with a suspected platelet function defect (PFD), and its use has also been proposed for assessing the efficacy of antiplatelet treatment (APT). An automated LTA method has been developed by Sysmex (Kobe, Japan) on a routine coagulation analyzer (CS-2400), together with a new research parameter called PAL (platelet aggregation level) to evaluate patients on APT.

Materials and methods

We evaluated the performance of CS-2400 compared to a stand-alone lumi-dual-aggregometer device in the diagnosis of PFD and in assessing the efficacy of APT. For these purposes, the study population was represented by a cohort of 23 patients with a previous diagnosis of

SUBMITTER: Lecchi A 

PROVIDER: S-EPMC11251833 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature