Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China.

ABSTRACT:

Background

The aetiology of lung cancer among individuals who never smoked remains elusive, despite 15% of lung cancer cases in men and 53% in women worldwide being unrelated to smoking. Epigenetic alterations, particularly DNA methylation (DNAm) changes, have emerged as potential drivers. Yet, few prospective epigenome-wide association studies (EWAS), primarily focusing on peripheral blood DNAm with limited representation of never smokers, have been conducted.

Methods

We conducted a nested case-control study of 80 never-smoking incident lung cancer cases and 83 never-smoking controls within the Shanghai Women's Health Study and Shanghai Men's Health Study. DNAm was measured in prediagnostic oral rinse samples using Illumina MethylationEPIC array. Initially, we conducted an

SUBMITTER: Rahman ML 

PROVIDER: S-EPMC11251856 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature