Transcriptomic Profiles Associated with Experimental Placebo Effects in Chronic Pain.

ABSTRACT: Gene expression networks associated with placebo effects are understudied; in this study, we identified transcriptomic profiles associated with placebo responsivity. Participants suffering from chronic pain underwent a verbal suggestion and conditioning paradigm with individually tailored thermal painful stimulations to elicit conditioned placebo effects. Participants reported pain intensity on a visual analog scale (VAS) anchored from zero = no pain to 100 = maximum imaginable pain. RNA was extracted from venous blood and RNA sequencing and validation tests were performed to identify differentially expressed genes (DEGs) associated with placebo effects, controlling for sex and level of pain. Unbiased enrichment analyses were performed to identify biological processes associated with place

SUBMITTER: Colloca L 

PROVIDER: S-EPMC11251865 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature