Common functional mechanisms underlying dynamic brain network changes across five general anesthetics: A rat fMRI study.

ABSTRACT:

Background

Reversible loss of consciousness is the primary therapeutic endpoint of general anesthesia; however, the drug-invariant mechanisms underlying anesthetic-induced unconsciousness are still unclear. This study aimed to investigate the static, dynamic, topological and organizational changes in functional brain network induced by five clinically-used general anesthetics in the rat brain.

Method

Male Sprague-Dawley rats (n = 57) were randomly allocated to received propofol, isoflurane, ketamine, dexmedetomidine, or combined isoflurane plus dexmedetomidine anesthesia. Resting-state functional magnetic resonance images were acquired under general anesthesia and analyzed for changes in dynamic functional brain networks compared to the awake state.

Results

Different

SUBMITTER: Chen S 

PROVIDER: S-EPMC11251872 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature