Collagen concentration regulates neutrophil extravasation and migration in response to infection in an endothelium dependent manner.

ABSTRACT:

Introduction

As the body's first line of defense against disease and infection, neutrophils must efficiently navigate to sites of inflammation; however, neutrophil dysregulation contributes to the pathogenesis of numerous diseases that leave people susceptible to infections. Many of these diseases are also associated with changes to the protein composition of the extracellular matrix. While it is known that neutrophils and endothelial cells, which play a key role in neutrophil activation, are sensitive to the mechanical and structural properties of the extracellular matrix, our understanding of how protein composition in the matrix affects the neutrophil response to infection is incomplete.

Methods

To investigate the effects of extracellular matrix composition on the neutrop

SUBMITTER: Calo CJ 

PROVIDER: S-EPMC11251947 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature