Dosimetric Comparison Between Proton and Photon Radiation Therapies for Pediatric Neuroblastoma.

ABSTRACT:

Purpose

The aim of this study is to determine the most beneficial radiation treatment technique for pediatric patients with thoracic and abdominal neuroblastoma (NBL), through a dosimetric comparison between photon Volumetric Modulated Arc Therapy and proton Intensity-Modulated Proton Therapy treatment plans.

Materials and methods

A retrospective analysis was conducted on a multicentre case series of 19 patients with thoracic and/or abdominal NBL who underwent radiation therapy, following the recommendations of the European protocol for high-risk NBL (HR-NBL2/SIOPEN). The prescribed dose was 21.6 Gy in 12 fractions (1.8 Gy/fraction) delivered over the preoperative disease volume. The dose volume histograms were analyzed for each patient, and a Wilcoxon signed-rank test with

SUBMITTER: Mirandola A 

PROVIDER: S-EPMC11252081 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature