AURKB promotes immunogenicity and immune infiltration in clear cell renal cell carcinoma.

ABSTRACT:

Background

Chromatin regulators (CRs) are capable of causing epigenetic alterations, which are significant features of cancer. However, the function of CRs in controlling Clear Cell Renal Cell Carcinoma (ccRCC) is not well understood. This research aims to discover a CRs prognostic signature in ccRCC and to elucidate the roles of CRs-related genes in tumor microenvironment (TME).

Methods

Expression profiles and relevant clinical annotations were retrieved from the Cancer Genome Atlas (TCGA) and UCSC Xena platform for progression-free survival (PFS) data. The R package "limma" was used to identify differentially expressed CRs. A predictive model based on five CRs was developed using LASSO-Cox analysis. The model's predictive power and applicability were validated using K-M cu

SUBMITTER: Liu W 

PROVIDER: S-EPMC11252114 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature