Divergent evolution of male-determining loci on proto-Y chromosomes of the housefly.

ABSTRACT: Houseflies provide a good experimental model to study the initial evolutionary stages of a primary sex-determining locus because they possess different recently evolved proto-Y chromosomes that contain male-determining loci (M) with the same male-determining gene, Mdmd. We investigate M-loci genomically and cytogenetically revealing distinct molecular architectures among M-loci. M on chromosome V (M^V) has two intact Mdmd copies in a palindrome. M on chromosome III (M^III) has tandem duplications containing 88 Mdmd copies (only one intact) and various repeats, including repeats that are XY-prevalent. M on chromosome II (M^II) and the Y (M^Y) share M^III-like architecture, but with fewer repeats. M^Y additionally shares M^V

SUBMITTER: Li X 

PROVIDER: S-EPMC11252125 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature