Cellular heterogeneity and key subsets of tissue-resident memory T cells in cervical cancer.

ABSTRACT: Tissue-resident memory T cells (TRMs) play a critical role in cancer immunity by offering quick and effective immune responses. However, the cellular heterogeneity of TRMs and their significance in cervical cancer (CC) remain unknown. In this study, we generated and analyzed single-cell RNA sequencing data from 12,945 TRMs (ITGAE⁺ CD3D⁺) and 25,627 non-TRMs (ITGAE^- CD3D⁺), derived from 11 CC tissues and 5 normal cervical tissues. We found that TRMs were more immunoreactive than non-TRMs, and TRMs in CC tissues were more activated than those in normal cervical tissues. Six CD8⁺ TRM subclusters and one CD4⁺ TRM subcluster were identified. Among them, CXCL13⁺ CD8⁺ TRMs were more abundant in CC tissues than

SUBMITTER: Wang F 

PROVIDER: S-EPMC11252146 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature