Metabolic insights into HIV/TB co-infection: an untargeted urinary metabolomics approach.

ABSTRACT:

Introduction

Amid the global health crisis, HIV/TB co-infection presents significant challenges, amplifying the burden on patients and healthcare systems alike. Metabolomics offers an innovative window into the metabolic disruptions caused by co-infection, potentially improving diagnosis and treatment monitoring.

Aim

This study uses untargeted metabolomics to investigate the urinary metabolic signature of HIV/TB co-infection, enhancing understanding of the metabolic interplay between these infections.

Methods

Urine samples from South African adults, categorised into four groups - healthy controls, TB-positive, HIV-positive, and HIV/TB co-infected - were analysed using GCxGC-TOFMS. Metabolites showing significant differences among groups were identified through Kruskal

SUBMITTER: Olivier C 

PROVIDER: S-EPMC11252185 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature