Metabolic imaging across scales reveals distinct prostate cancer phenotypes.

ABSTRACT: Hyperpolarised magnetic resonance imaging (HP-¹³C-MRI) has shown promise as a clinical tool for detecting and characterising prostate cancer. Here we use a range of spatially resolved histological techniques to identify the biological mechanisms underpinning differential [1-¹³C]lactate labelling between benign and malignant prostate, as well as in tumours containing cribriform and non-cribriform Gleason pattern 4 disease. Here we show that elevated hyperpolarised [1-¹³C]lactate signal in prostate cancer compared to the benign prostate is primarily driven by increased tumour epithelial cell density and vascularity, rather than differences in epithelial lactate concentration between tumour and normal. We also demonstrate that some tumours of the cribriform su

SUBMITTER: Sushentsev N 

PROVIDER: S-EPMC11252279 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature