Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants.

ABSTRACT: The heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study evaluated the epigenetic contribution to SLE heterogeneity considering molecular and serological subtypes, genetics and transcriptional status, followed by drug target discovery. We performed a stratified epigenome-wide association studies of whole blood DNA methylation from 213 SLE patients and 221 controls. Methylation quantitative trait loci analyses, cytokine and transcription factor activity - epigenetic associations and methylation-expression correlations were conducted. New drug targets were searched for based on differentially methylated genes. In a stratified approach, a total of 974 differenti

SUBMITTER: Castellini-Perez O 

PROVIDER: S-EPMC11252280 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature