Causality of genetically determined blood metabolites on inflammatory bowel disease: a two-sample Mendelian randomization study.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disease of the gastrointestinal tract, including two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). Metabolic disorders are important factors in the development of IBD. However, the evidence for the causal relationship between blood metabolites and IBD remains limited. A two-sample MR analysis was applied to evaluate relationships between 486 blood metabolites and IBD. The inverse variance weighted method was chosen as the primary MR analysis method. False discovery rate correction was used to control for false positives in multiple testing. Following complementary and sensitivity analyses were conducted using methods such as weight median, MR-egger, weighted mode, simple mode, Cochran Q test, and MR-PRES

SUBMITTER: Long X 

PROVIDER: S-EPMC11252329 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature