A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment.

ABSTRACT: Aging involves the deterioration of organismal function, leading to the emergence of multiple pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this process and may be used as tools in the pursuit of healthy aging. To evaluate the role of epigenetic mechanisms in this context, we have generated bulk tissue and single cell multi-omic maps of the male mouse dorsal hippocampus in young and old animals exposed to environmental stimulation in the form of enriched environments. We present a molecular atlas of the aging process, highlighting two distinct axes, related to inflammation and to the dysregulation of mRNA metabolism, at the functional RNA and protein level. Additionally, we report the alteration of heterochromatin domains, including the loss of bi

SUBMITTER: Perez RF 

PROVIDER: S-EPMC11252340 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature