Epidermal growth factor-like domain 7 drives brain lymphatic endothelial cell development through integrin αvβ3.

ABSTRACT: In zebrafish, brain lymphatic endothelial cells (BLECs) are essential for meningeal angiogenesis and cerebrovascular regeneration. Although epidermal growth factor-like domain 7 (Egfl7) has been reported to act as a pro-angiogenic factor, its roles in lymphangiogenesis remain unclear. Here, we show that Egfl7 is expressed in both blood and lymphatic endothelial cells. We generate an egfl7 ^cq180 mutant with a 13-bp-deletion in exon 3 leading to reduced expression of Egfl7. The egfl7 ^cq180 mutant zebrafish exhibit defective formation of BLEC bilateral loop-like structures, although trunk and facial lymphatic development remains unaffected. Moreover, while the egfl7 ^cq180 mutant displays normal BLEC lineage specification, the migration and proliferation of the

SUBMITTER: Chen J 

PROVIDER: S-EPMC11252342 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature