Comprehensive landscape of m6A regulator-related gene patterns and tumor microenvironment infiltration characterization in gastric cancer.

ABSTRACT: The epigenetic regulation of N6-methyladenosine (m⁶A) has attracted considerable interest in tumor research, but the potential roles of m⁶A regulator-related genes, remain largely unknown within the context of gastric cancer (GC) and tumor microenvironment (TME). Here, a comprehensive strategy of data mining and computational biology utilizing multiple datasets based on 28 m⁶A regulators (including novel anti-readers) was employed to identify m⁶A regulator-related genes and patterns and elucidate their underlying mechanisms in GC. Subsequently, a scoring system was constructed to evaluate individual prognosis and immunotherapy response. Three distinct m⁶A regulator-related patterns were identified through the unsupervised clustering of

SUBMITTER: Peng B 

PROVIDER: S-EPMC11252343 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature