Anti-inflammatory response to 1,8-Cineol and associated microbial communities in Otitis media patients.

ABSTRACT: Chronic Otitis Media (COM) is defined as long term inflammation and colonization with pathogenic bacteria due to a defect or retraction of the tympanic membrane. Surgical interventions are often augmented by antibiotic resistance development and therefore, off-label treatment using the natural drug 1,8-Cineol was carried out. All COM patients underwent antibiotic therapy and middle ear surgery and developed antibiotic resistances. Microbiological investigations from the auditory canal and stool samples were performed in correlation with the clinical course. Therapy of COM patients with 1,8-Cineol revealed a clear reduction of inflammatory microbes P. aeruginosa and Proteus mirabilis in ear samples as well as intestinal Prevotella copri, which was associated with an improved clinical outcom

SUBMITTER: Leichtle A 

PROVIDER: S-EPMC11252366 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature