Enhancing the performance of porous silicon biosensors: the interplay of nanostructure design and microfluidic integration.

ABSTRACT: This work presents the development and design of aptasensor employing porous silicon (PSi) Fabry‒Pérot thin films that are suitable for use as optical transducers for the detection of lactoferrin (LF), which is a protein biomarker secreted at elevated levels during gastrointestinal (GI) inflammatory disorders such as inflammatory bowel disease and chronic pancreatitis. To overcome the primary limitation associated with PSi biosensors-namely, their relatively poor sensitivity due to issues related to complex mass transfer phenomena and reaction kinetics-we employed two strategic approaches: First, we sought to optimize the porous nanostructure with respect to factors including layer thickness, pore diameter, and capture probe density. Second, we leveraged convection properties by integratin

SUBMITTER: Awawdeh K 

PROVIDER: S-EPMC11252414 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature