Gene mutations in newly diagnosed multiple myeloma patients detected by next-generation sequencing technology.

ABSTRACT:

Background

Multiple myeloma (MM) is a heterogeneous plasma-derived hematopoietic malignancy with complex genetic mutation contributing to the pathogenesis. Though gene sequencing has been applied in MM, genetic features from Chinese MM patients are reported less. We investigated the genetic mutation of newly diagnosed multiple myeloma (NDMM) patients and explore its correlation with cytogenetic abnormalities detected by fluorescence in situ hybridization (FISH).

Methods

A total of 206 patients with NDMM were enrolled. After enriching plasma cells with CD138 magnetic beads, 92 MM-related target gene mutations were detected by the Illumina sequencing platform, and six common genetic abnormalities were detected by FISH.

Results

162 cases (78.6%) had at least one g

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11252513 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature