Insulin resistance is an integral feature of MASLD even in the presence of PNPLA3 variants.

ABSTRACT:

Background & aims

It has been postulated that carriers of PNPLA3 I148M (CG [Ile/Met] or GG [Met/Met]) develop metabolic dysfunction-associated steatotic liver disease (MASLD) in the absence of insulin resistance or metabolic syndrome. However, the relationship between insulin resistance and MASLD according to the PNPLA3 allele has not been carefully assessed.

Methods

A total of 204 participants were recruited and underwent PNPLA3 genotyping, an oral glucose tolerance test, liver proton magnetic resonance spectroscopy and percutaneous liver biopsy if diagnosed with MASLD. A subgroup of patients (n = 55) had an euglycemic hyperinsulinemic clamp with glucose tracer infusion.

Results

As expected, patients with the CG/GG genotype had worse intrahepatic trigly

SUBMITTER: Bril F 

PROVIDER: S-EPMC11252529 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature