Chaos control in cardiac dynamics: terminating chaotic states with local minima pacing.

ABSTRACT: Current treatments of cardiac arrhythmias like ventricular fibrillation involve the application of a high-energy electric shock, that induces significant electrical currents in the myocardium and therefore involves severe side effects like possible tissue damage and post-traumatic stress. Using numerical simulations on four different models of 2D excitable media, this study demonstrates that low energy pulses applied shortly after local minima in the mean value of the transmembrane potential provide high success rates. We evaluate the performance of this approach for ten initial conditions of each model, ten spatially different stimuli, and different shock amplitudes. The investigated models of 2D excitable media cover a broad range of dominant frequencies and number of phase singularities

SUBMITTER: Suth D 

PROVIDER: S-EPMC11252590 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature