Clinical and Immunological Features, Genetic Variants, and Outcomes of Patients with CD40 Deficiency.

ABSTRACT:

Purpose

Inherited deficiencies of CD40 and CD40 ligand (CD40L) reflect the crucial immunological functions of CD40-CD40L interaction/signaling. Although numerous studies have provided a detailed description of CD40L deficiency, reports of CD40 deficiency are scarce. Herein, we describe the characteristics of all reported patients with CD40 deficiency.

Methods

The PubMed, Embase and Web of Science databases were searched for relevant literature published till 7th August 2023. Study deduplication and identification of relevant reports was performed using the online PICO Portal. The data were extracted using a pre-designed data extraction form and the SPSS software was used for analysis.

Results

Systematic literature review revealed 40 unique patients with CD40 deficienc

SUBMITTER: Banday AZ 

PROVIDER: S-EPMC11252661 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature