Alzheimer Disease and Related Dementia Following Hormone-Modulating Therapy in Patients With Breast Cancer.

ABSTRACT:

Importance

Hormone-modulating therapy (HMT) is a widely accepted treatment for hormone receptor-positive breast cancer, although its cognitive effects, including a potential link to Alzheimer disease and related dementias (ADRD), remain understudied.

Objective

To investigate the association between HMT for breast cancer treatment and risk of developing ADRD in women aged 65 years or older.

Design, setting, and participants

This cohort study used a comprehensive dataset from the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database to identify patients who did and did not receive HMT treatment within 3 years after the initial diagnosis of breast cancer and assessed their risk of developing ADRD in later life. Individuals with a preexisting diagnos

SUBMITTER: Cai C 

PROVIDER: S-EPMC11252894 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature