A novel nomogram model for lung adenocarcinoma subtypes based on RNA-modification regulatory genes.

ABSTRACT:

Background

In non-small cell lung cancer (NSCLC), lung adenocarcinoma (LUAD) is the most common subtype. RNA modification has become the frontier and hotspot of current tumor research.

Results

In this study, 109 genes that regulate RNA modifications were identified according to The Cancer Genome Atlas (TCGA). A differential gene expression analysis identified 46 differentially expressed RNA modification regulatory genes (DERRGs). LUAD samples were stratified into two distinct clusters based on the expression of these DERRGs. A significant correlation was observed between these clusters and patient survival rates, as well as clinical features. Furthermore, a four-DERRG signature (EIF3B, HNRNPC, IGF2BP1, and METTL3) developed using LASSO regression. According to the calculated

SUBMITTER: Chen X 

PROVIDER: S-EPMC11252981 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature