Comprehensive Analysis of angiogenesis associated genes and tumor microenvironment infiltration characterization in cervical cancer.

ABSTRACT:

Background

Cervical cancer is among the most prevalent malignancies worldwide. This study explores the relationships between angiogenesis-related genes (ARGs) and immune infiltration, and assesses their implications for the prognosis and treatment of cervical cancer. Additionally, it develops a diagnostic model based on angiogenesis-related differentially expressed genes (ARDEGs).

Methods

We systematically evaluated 15 ARDEGs using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA), and Gene Set Variation Analysis (GSVA). Immune cell infiltration was assessed using a single-sample gene-set enrichment analysis (ssGSEA) algorithm. We then constructed a diagnostic model for ARDEGs using Least Absolute Shrinkage and Selection

SUBMITTER: Li S 

PROVIDER: S-EPMC11252983 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature