Development of an aptasensor for highly sensitive detection of cardiac troponin I using cobalt-nickel metal-organic framework (CoNi-MOF).

ABSTRACT:

Objective and rationale

This study aimed to develop a highly sensitive and selective single-stranded DNA (ssDNA) aptamer targeting cardiac troponin I (cTnI), a crucial biomarker for acute myocardial infarction (AMI). The objective was to fabricate a novel aptamer electrochemical sensor using a composite material of cobalt-nickel metal-organic framework (CoNi-MOF) on screen-printed carbon electrodes (SPCE), leveraging the composite's large surface area and excellent electrical conductivity alongside the aptamer's high affinity for cTnI.

Methods

The aptamer electrochemical sensor was fabricated using the CoNi-MOF composite on SPCE and characterized its properties. They conducted electrochemical measurements to assess the sensor's performance in detecting cTnI. The sensor's sta

SUBMITTER: Devaraj R 

PROVIDER: S-EPMC11253065 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature