Extranodal Extension Improves AJCC-8 Accuracy in HPV+ Oropharyngeal Cancer in a High-Risk Population.

ABSTRACT:

Objectives

The American Joint Committee on Cancer's 8th edition (AJCC-8) separates oropharyngeal squamous cell carcinomas (OPSCCs) into human papillomavirus-positive (HPV+) tumors and HPV-negative tumors. Although AJCC-8 improves prognostic prediction for survival for the majority of HPV+ OPSCC, outliers are still encountered. The goal of this manuscript is to validate the AJCC-8 as a better metric of survivability than the AJCC-7 in an historically under-served rural population with confounding variables, such as tobacco use, alcohol consumption, and poor health care access and to analyze the role of extranodal extension (ENE) in this population.

Design

Retrospective cohort study.

Results

Compared to AJCC-7, AJCC-8 had a higher odds ratio (OR) for predicting mortalit

SUBMITTER: Burruss CP 

PROVIDER: S-EPMC11253244 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature