Inhalation of hydrogen gas protects against mitomycin-induced pulmonary veno-occlusive disease.

ABSTRACT:

Background

As a subtype of pulmonary hypertension (PH), pulmonary veno-occlusive disease (PVOD) is devastating and life-threatening disease without effective therapy. Hydrogen has been reported to exhibits antioxidant and anti-inflammatory effects in a rat model induced by monocrotaline of PH. In this study, we investigated the effects of inhaled hydrogen gas on the prevention and treatment of PVOD induced by mitomycin C (MMC) in rats.

Methods

PVOD was induced in female Sprague-Dawley rats through intraperitoneal injection of MMC at a concentration of 3 mg·kg^- 1·wk^- 1 for 2 weeks. Inhalation of hydrogen gas (H₂) was administered through a designed rat cage concurrently or two weeks after MMC administration. The severity of PVOD was assessed b

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11253336 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature