Endogenous and exogeneous stimuli-triggered reactive oxygen species evoke long-lived carbon monoxide to fight against lung cancer.

ABSTRACT: Reactive oxygen species (ROS)-associated anticancer approaches usually suffer from two limitations, i.e., insufficient ROS level and short ROS half-life. Nevertheless, no report has synchronously addressed both concerns yet. Herein, a multichannel actions-enabled nanotherapeutic platform using hollow manganese dioxide (H-MnO₂) carriers to load chlorin e6 (Ce6) sonosensitizer and CO donor (e.g., Mn₂(CO)₁₀) has been constructed to maximumly elevate ROS level and trigger cascade catalysis to produce CO. Therein, intratumoral H₂O₂ and ultrasound as endogenous and exogeneous triggers stimulate H-MnO₂ and Ce6 to produce •OH and ¹O₂, respectively. The further cascade reaction between ROS and Mn₂(CO)

SUBMITTER: Fang Y 

PROVIDER: S-EPMC11253342 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature