CREdb: A comprehensive database of Cis-Regulatory Elements and their activity in human cells and tissues.

ABSTRACT:

Background

Cis-regulatory elements (CREs) play a pivotal role in gene expression regulation, allowing cells to serve diverse functions and respond to external stimuli. Understanding CREs is essential for personalized medicine and disease research, as an increasing number of genetic variants associated with phenotypes and diseases overlap with CREs. However, existing databases often focus on subsets of regulatory elements and present each identified instance of element individually, confounding the effort to obtain a comprehensive view. To address this gap, we have created CREdb, a comprehensive database with over 10 million human regulatory elements across 1,058 cell types and 315 tissues harmonized from different data sources. We curated and aligned the cell types and tissues to s

SUBMITTER: Hartl C 

PROVIDER: S-EPMC11253421 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature