Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes.

ABSTRACT:

Background

Sepsis poses a grave threat, especially among children, but treatments are limited owing to heterogeneity among patients. We sought to test the clinical and biological relevance of pediatric septic shock subclasses identified using reproducible approaches.

Methods

We performed latent profile analyses using clinical, laboratory, and biomarker data from a prospective multi-center pediatric septic shock observational cohort to derive phenotypes and trained a support vector machine model to assign phenotypes in an internal validation set. We established the clinical relevance of phenotypes and tested for their interaction with common sepsis treatments on patient outcomes. We conducted transcriptomic analyses to delineate phenotype-specific biology and inferred underly

SUBMITTER: Atreya MR 

PROVIDER: S-EPMC11253460 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature