Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

This study aims to explore the bidirectional causal relationship between immune cell phenotypes and chronic periodontitis using a Mendelian randomization framework.

Materials and methods

Through a two-sample Mendelian randomization analysis, this research examined genetic data related to 731 immune cell traits and chronic periodontitis. Instrumental variables were chosen based on their genetic links to either immune traits or periodontitis. Various statistical techniques, including MR-Egger regression, weighted median, and inverse-variance weighted (IVW) analysis, were employed to determine the causal connections.

Results

Predominantly using the IVW method, 26 distinct immune phenotypes were identified as potentially influencing periodontitis (P < 0.05). Co

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11253491 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature