Coordinated adaptation of Staphylococcus aureus to calprotectin-dependent metal sequestration.

ABSTRACT: The host protein calprotectin inhibits the growth of a variety of bacterial pathogens through metal sequestration in a process known as "nutritional immunity." Staphylococcus aureus growth is inhibited by calprotectin in vitro, and calprotectin is localized in vivo to staphylococcal abscesses during infection. However, the staphylococcal adaptations that provide defense against nutritional immunity and the role of metal-responsive regulators are not fully characterized. In this work, we define the transcriptional response of S. aureus and the role of the metal-responsive regulators, Zur, Fur, and MntR, in response to metal limitation by calprotectin exposure. Additionally, we identified genes affecting the fitness of S. aureus during metal limitation thro

SUBMITTER: Reyes Ruiz VM 

PROVIDER: S-EPMC11253595 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature