Complex relationships of socioeconomic status with vascular and Alzheimer's pathways on cognition.

ABSTRACT:

Introduction

AD and CVD, which frequently co-occur, are leading causes of age-related cognitive decline. We assessed how demographic factors, socioeconomic status (SES) as indicated by education and occupation, vascular risk factors, and a range of biomarkers associated with both CVD (including white matter hyperintensities [WMH], diffusion MRI abnormalities, infarctions, and microbleeds) and AD (comprising amyloid-PET and tau-PET) collectively influence cognitive function.

Methods

In this cross-sectional population study, structural equation models were utilized to understand these associations in 449 participants (mean age (SD) = 74.5 (8.4) years; 56% male; 7.5% cognitively impaired).

Results

(1) Higher SES had a protective effect on cognition with mediation through

SUBMITTER: Shir D 

PROVIDER: S-EPMC11253683 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature