Plasma p-tau217 concordance with amyloid PET among ethnically diverse older adults.

ABSTRACT:

Introduction

Commercially available plasma p-tau217 biomarker tests are not well studied in ethnically diverse samples.

Methods

We evaluated associations between ALZPath plasma p-tau217 and amyloid-beta positron emission tomography (Aβ-PET) in Hispanic/Latino (88% of Cuban or South American ancestry) and non-Hispanic/Latino older adults. One- and two-cutoff ranges were derived and evaluated to assess agreement with Aβ-PET.

Results

A total of 239 participants underwent blood draw and Aβ-PET (age 70.8 ± 7.8, 55.2% female, education 15.6 ± 3.4 years, 48.9% Hispanic/Latino, 94.9% white). Plasma p-tau217 showed excellent discrimination of Aβ-PET positive and negative participants (visual read: AUC = 0.91 [0.87-0.95], p < 0.001; Centiloids quantification: AUC = 0.90

SUBMITTER: Asken BM 

PROVIDER: S-EPMC11253830 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature