Synthesis, biological evaluation and metadynamics simulations of novel <i>N</i>-methyl β-sheet breaker peptides as inhibitors of Alzheimer's β-amyloid fibrillogenesis.

ABSTRACT: Several scientific evidences report that a central role in the pathogenesis of Alzheimer's disease is played by the deposition of insoluble aggregates of β-amyloid proteins in the brain. Because Aβ is self-assembling, one possible design strategy is to inhibit the aggregation of Aβ peptides using short peptide fragments homologous to the full-length wild-type Aβ protein. In the past years, several studies have reported on the synthesis of some short synthetic peptides called β-sheet breaker peptides (BSBPs). Herein, we present the synthesis of novel (cell-permeable) N-methyl BSBPs, designed based on literature information on the structural key features of BSBPs. Three-dimensional GRID-based pharmacophore peptide screening combined with PT-WTE metadynamics was performed to support th

SUBMITTER: Moraca F 

PROVIDER: S-EPMC11253850 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature