Modeling the impact of neuromorphological alterations in Down syndrome on fast neural oscillations.

ABSTRACT: Cognitive disorders, including Down syndrome (DS), present significant morphological alterations in neuron architectural complexity. However, the relationship between neuromorphological alterations and impaired brain function is not fully understood. To address this gap, we propose a novel computational model that accounts for the observed cell deformations in DS. The model consists of a cross-sectional layer of the mouse motor cortex, composed of 3000 neurons. The network connectivity is obtained by accounting explicitly for two single-neuron morphological parameters: the mean dendritic tree radius and the spine density in excitatory pyramidal cells. We obtained these values by fitting reconstructed neuron data corresponding to three mouse models: wild-type (WT), transgenic (TgDyrk1A), an

SUBMITTER: Clusella P 

PROVIDER: S-EPMC11253980 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature